OpenFold Cofolding

Fold a protein sequence together with a ligand, and look at the complex.

Protein

One chain, as FASTA. The example is the TYK2 pseudokinase domain construct the OpenFE cookbook folds.

Sequence0 residuesChain id

LigandSDF fileor keep the loaded TYK2 seriesMolecule0 in this file

OpenFold3 runLigand chain id

SeedSamplesper query

Structure formatOpenFE needs PDB; mmCIF is the runner's default

The demo backend returns precomputed OpenFold3 output for the ten TYK2 ligands (seed 42, sample 1). A different ligand still submits and uploads for real, but the structure that comes back is the first of that series.

This ligand has no SMILES, which every backend requires.

Submit→Upload→Poll→Done

Run the workflow to see outputs here.